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You can flip a manifested card face up at any time you have priority , but only if its actually a creature card with a mana cost

It lets you Sacrifice a creature at Instant speed, no extra tapping, mana, or resources required

I think Sliver Queen is overall the strongest commander for this restriction, and I did brew a deck around her, but ultimately for Commander Clash I wanted to go with something even more iconic so I went with Vaevictis Asmadi

However, there are still formidable characters and strategies to mention

They tend to be painfully linear, rely heavily on "lords", fold pathetically to sweepers, and really have very little to differentiate themselves from one another