DBCO-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-PNP Size:50mg 644 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCC#C)CCN(CC(O)=O)CC1 Purity (HPLC)

644 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCC#C)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

while the para-aminobenzyl (PAB) spacer supports self-immolative release of the attached drug

Product Name DOTA-C6-amine Synonyms CAS Number n/a Related CAS Molecular Formula C22H42N6O7 Molecular Weight 502

Product Name Azide-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C86H136N14O23 Molecular Weight 1734

486 SMILES: NCCCCCNC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC=C(O)C=C2OC2=C1C=CC(O)=C2 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

DBCO-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-PNP Size:50mg 644 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCC#C)CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to